Nicastrin antibody (AA 21-120) (AbBy Fluor® 750)

Catalog No. ABIN5007636

This Rabbit Polyclonal antibody specifically detects Nicastrin in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for Nicastrin antibody (AA 21-120) (AbBy Fluor® 750) (ABIN5007636)

Target: Nicastrin (NCSTN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nicastrin antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Nicastrin Antibody (AbBy Fluor® 750)

Binding Specificity: AA 21-120

Purpose: Nicastrin Polyclonal Antibody, AbBy Fluor-750 Conjugated

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Nicastrin

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Nicastrin

Target: Nicastrin (NCSTN)

Alternative Name: Nicastrin

Background:

Synonyms: ATAG1874, Nicastrin, NCSTN, KIAA0253, UNQ1874/PRO4317

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

Gene ID: 23385

UniProt: Q92542

Pathways: Notch Signaling, Neurotrophin Signaling Pathway