ASAP1 antibody (AA 912-1115)

Catalog No. ABIN5027041

Product Details anti-ASAP1 Antibody

Target: ASAP1 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1 (ASAP1))

Binding Specificity: AA 912-1115

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASAP1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant ASAP1 protein (amino acids 912-1115) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for ASAP1

Target: ASAP1 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1 (ASAP1))

Alternative Name: ASAP1 (ASAP1 Products)

Synonyms: AV239055 antibody, DEF-1 antibody, Ddef1 antibody, PAP antibody, mKIAA1249 antibody, s19 antibody, AMAP1 antibody, CENTB4 antibody, DDEF1 antibody, PAG2 antibody, ZG14P antibody, ASAP1 antibody, ddef1 antibody, Asap1 antibody, si:ch211-160i2.3 antibody, ArfGAP with SH3 domain, ankyrin repeat and PH domain1 antibody, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 antibody, toxic extracellular endopeptidase antibody, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 L homeolog antibody, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a antibody, Asap1 antibody, ASAP1 antibody, asaP1 antibody, asap1 antibody, asap1.L antibody, asap1a antibody

Background: ASAP (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1) or Development and differentiation-enhancing factor 1 or DDEF1 is an ADP-ribosylation factor (ARF) GTPase-activating protein with two known isoforms: ASAP1a and ASAP1b (125 and 126 kDa, respectively). ASAP contains a pleckstrin homology (PH) domain, a zinc finger motif, 3 ankyrin repeats, a proline-rich region containing several SH3 ligand motifs, and an SH3 domain. GTPase-activating property of ASAP1 is induced by phosphatidylinositol 4,5-biphosphate (PIP2) of the PH domain. ASAP1 plays an important role in cytoskeleton remodeling and regulation of membrane trafficking. ASAP1 acts as a proto-oncogene in breast cancer and other malignant tumors. ASAP is highly expressed in brain tissue.

Molecular Weight: 115 kDa

Gene ID: 13196

UniProt: Q9QWY8