TIA1 antibody (AA 182-385)

Catalog No. ABIN5027559

This Mouse Monoclonal antibody specifically detects TIA1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for TIA1 antibody (AA 182-385) (ABIN5027559)

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: ABM47E1

Product Details anti-TIA1 Antibody

Binding Specificity: AA 182-385

Purification: Protein G Chromatography

Immunogen: A partial length recombinant TIA-1 protein (amino acids 182-385) was used as the immunogen for this antibody.

Isotype: IgG1

Application Details

Application Notes: WB: 2-4 μg/mL, IHC: 5-10 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for TIA1

Target: TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))

Alternative Name: TIA-1

Background: TIA1 (T-cell intracellular antigen) are mRNA-binding proteins that can aggregate within granules under specific stress conditions. TIA-1 is a multi-domain ribonucleic acid (RNA) binding protein that recognizes poly-uridine tract RNA sequences to facilitate 5'splice site recognition by the U1 small nuclear ribonucleoprotein (snRNP). TIA1 mutation causes perturbed RNA splicing and cellular stress resulting in WDM (Welander distal myopathy). TIA-1 regulates developmental and stress-responsive pathways through distinct activities at the levels of alternative pre-mRNA splicing and mRNA translation by recognising uridine-rich sequences of RNAs.

Molecular Weight: 44 kDa

Gene ID: 7072

UniProt: P31483