CRBN antibody (AA 1-442)

Catalog No. ABIN526543

This Mouse Polyclonal antibody specifically detects CRBN in WB. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for CRBN antibody (AA 1-442) (ABIN526543)

Target: CRBN (Cereblon (CRBN))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This CRBN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CRBN Antibody

Binding Specificity: AA 1-442

Purpose: Mouse polyclonal antibody raised against a full-length human CRBN protein.

Sequence: MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF AVLAYSNVQE REAQFGTTAE IYAYREEQDF GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA KVQILPECVL PSTMSAVQLE SLNKCQIFPS KPVSREDQCS YKWWQKYQKR KFHCANLTSW PRWLYSLYDA ETLMDRIKKQ LREWDENLKD DSLPSNPIDF SYRVAACLPI DDVLRIQLLK IGSAIQRLRC ELDIMNKCTS LCCKQCQETE ITTKNEIFSL SLCGPMAAYV NPHGYVHETL TVYKACNLNL IGRPSTEHSW FPGYAWTVAQ CKICASHIGW KFTATKKDMS PQKFWGLTRS ALLPTIPDTE DEISPDKVIL CL

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: CRBN (NP_057386.2, 1 a.a. ~ 442 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CRBN antibody (ABIN526543)

Peng, Li, Clarkson, Pehar, Lao, Hillmer, Barnhart, Christian, Mitchell, Bendlin, Sandor, Puglielli: "Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 20, pp. 6772-89, (2014) (PubMed).

Liu, Ye, Zou, Xu, Feng, Zou, Chen, Li, Cang: "CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis." in: Nature communications, Vol. 5, pp. 3924, (2014) (PubMed).

Charoenfuprasert, Yang, Lee, Chao, Chu, Lai, Hsu, Chang, Chen, Chen, Chang, Leu, Shih: "Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer." in: Oncogene, Vol. 30, Issue 33, pp. 3570-84, (2011) (PubMed).

Target Details for CRBN

Target: CRBN (Cereblon (CRBN))

Alternative Name: CRBN

Background: Full Gene Name: cereblon
Synonyms: DKFZp781K0715,MGC27358,MRT2A

Gene ID: 51185

NCBI Accession: NM_016302