FBXW7 antibody (AA 599-707)

Catalog No. ABIN527479

This Mouse Monoclonal antibody specifically detects FBXW7 in WB, ELISA and IHC (p). It exhibits reactivity toward Human and has been mentioned in 5+ publications.

Quick Overview for FBXW7 antibody (AA 599-707) (ABIN527479)

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FBXW7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3D1

Product Details anti-FBXW7 Antibody

Binding Specificity: AA 599-707

Purpose: Mouse monoclonal antibody raised against a partial recombinant FBXW7.

Sequence: ADSTVKIWDI KTGQCLQTLQ GPNKHQSAVT CLQFNKNFVI TSSDDGTVKL WDLKTGEFIR NLVTLESGGS GGVVWRIRAS NTKLVCAVGS RNGTEETKLL VLDFDVDMK

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: FBXW7 (NP_361014, 599 a.a. ~ 707 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-FBXW7 antibody (ABIN527479)

Hua, Ding, Yang: "Dysfunction of microRNA-32 regulates ubiquitin ligase FBXW7 in multiple myeloma disease." in: OncoTargets and therapy, Vol. 9, pp. 6573-6579, (2016) (PubMed).

Yumimoto, Akiyoshi, Ueo, Sagara, Onoyama, Ueo, Ohno, Mori, Mimori, Nakayama: "F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner." in: The Journal of clinical investigation, Vol. 125, Issue 2, pp. 621-35, (2015) (PubMed).

Yokobori, Yokoyama, Mogi, Endoh, Altan, Kosaka, Yamaki, Yajima, Tomizawa, Azuma, Onozato, Miyazaki, Tanaka, Kuwano: "FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs." in: Molecular cancer research : MCR, Vol. 12, Issue 1, pp. 32-7, (2014) (PubMed).

Lin, Hao, Nagata, Xu, Shang, Meng, Sato, Okuno, Varela, Ding, Garg, Liu, Yang, Yin, Shi, Jiang, Gu, Gong, Zhang, Xu, Kalid, Shacham, Ogawa, Wang, Koeffler: "Genomic and molecular characterization of esophageal squamous cell carcinoma." in: Nature genetics, Vol. 46, Issue 5, pp. 467-73, (2014) (PubMed).

Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: "Structural basis for a reciprocal regulation between SCF and CSN." in: Cell reports, Vol. 2, Issue 3, pp. 616-27, (2012) (PubMed).

Target Details for FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Alternative Name: FBXW7

Background: Full Gene Name: F-box and WD repeat domain containing 7
Synonyms: AGO,CDC4,DKFZp686F23254,FBW6,FBW7,FBX30,FBXO30,FBXW6,FLJ16457,SEL-10,SEL10

Gene ID: 55294

NCBI Accession: NM_033632

Pathways: Notch Signaling, EGFR Signaling Pathway