SIAH2 antibody (AA 1-100)

Catalog No. ABIN534023

Product Details anti-SIAH2 Antibody

Target: SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))

Binding Specificity: AA 1-100

Reactivity: Human, Pig, Drosophila melanogaster

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIAH2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purpose: Mouse monoclonal antibody raised against synthetic peptide of SIAH2.

Specificity: This antibody is specific to human SIAH2 and Drosophila SINA in proliferating cells and stem cells. This antibody does not detect Drosophila SINAH or normal, nondividing cells.

Cross-Reactivity: Drosophila melanogaster, Human, Pig

Immunogen: A synthetic peptide corresponding to amino acids 1-100 of drosophila SIAH2.

Clone: 24E6H3

Isotype: IgG1

Application Details

Application Notes: Immunocytochemistry (1:5-1:10)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:40-1:50)
Immunohistochemistry (Frozen sections) (1:40-1:50)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In tissue culture supernatant (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.

References for anti-SIAH2 antibody (ABIN534023)

Ahmed, Schmidt, Park, Reed, Hesse, Thomas, Molina, Deschamps, Yang, Aubry, Tang: "Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth." in: Journal of the National Cancer Institute, Vol. 100, Issue 22, pp. 1606-29, (2008) (PubMed).

Schmidt, Park, Ahmed, Gundelach, Reed, Cheng, Knudsen, Tang: "Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue." in: Cancer research, Vol. 67, Issue 24, pp. 11798-810, (2007) (PubMed).

Target Details for SIAH2

Target: SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))

Alternative Name: SIAH2 (SIAH2 Products)

Synonyms: hSiah2 antibody, Xsiah-2 antibody, siah2-A antibody, xsiah2 antibody, AA415433 antibody, Sinh2 antibody, siah E3 ubiquitin protein ligase 2 antibody, siah E3 ubiquitin protein ligase 2 L homeolog antibody, seven in absentia 2 antibody, SIAH2 antibody, siah2.L antibody, Siah2 antibody