NPC1 antibody (AA 1230-1278)

Catalog No. ABIN540364

Product Details anti-NPC1 Antibody

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Binding Specificity: AA 1230-1278

Reactivity: Human, Mouse, Hamster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunoelectron Microscopy (IEM)

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of NPC1.

Specificity: This antibody is specific to NPC1 protein.

Cross-Reactivity: Hamster, Human, Mouse

Immunogen: A synthetic peptide corresponding to amino acids 1230-1278 at C-terminus of human NPC1.

Application Details

Application Notes: Immunofluorescence (1:250)
Western Blot (1:1000-1:3000)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-NPC1 antibody (ABIN540364)

Burke, Colvin, Myatt, Graf, Schroeder, Woollett: "Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster." in: Journal of lipid research, Vol. 50, Issue 6, pp. 1146-55, (2009) (PubMed).

Millard, Srivastava, Traub, Schaffer, Ory: "Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis." in: The Journal of biological chemistry, Vol. 275, Issue 49, pp. 38445-51, (2001) (PubMed).

Frolov, Srivastava, Daphna-Iken, Traub, Schaffer, Ory: "Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function." in: The Journal of biological chemistry, Vol. 276, Issue 49, pp. 46414-21, (2001) (PubMed).

Target Details for NPC1

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Alternative Name: NPC1 (NPC1 Products)

Synonyms: NPC antibody, 9130221N23Rik antibody, Gm243 antibody, Cdig2 antibody, im:7149020 antibody, wu:fb53a12 antibody, wu:fc29a12 antibody, A430089E03Rik antibody, C85354 antibody, D18Ertd139e antibody, D18Ertd723e antibody, lcsd antibody, nmf164 antibody, spm antibody, NPC intracellular cholesterol transporter 1 antibody, NPC1 like intracellular cholesterol transporter 1 antibody, Niemann-Pick disease, type C1 antibody, Niemann-Pick C1 protein antibody, NPC1 antibody, Npc1l1 antibody, Npc1 antibody, npc1 antibody, LOC579887 antibody

Gene ID: 4864