ACE2 antibody (Internal Region)

Catalog No. ABIN541791

Product Details anti-ACE2 Antibody

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACE2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of ACE2.

Specificity: Anti-ACE2 has no cross response to ACE1.

Cross-Reactivity: Human, Mouse

Immunogen: A synthetic peptide corresponding to internal region of human ACE2.

Application Details

Application Notes: Western Blot (0.5-2 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.02 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-ACE2 antibody (ABIN541791)

Sahr, Wolke, Maczewsky, Krippeit-Drews, Tetzner, Drews, Venz, Gürtler, van den Brandt, Berg, Döring, Dombrowski, Walther, Lendeckel: "The Angiotensin-(1-7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo." in: Endocrinology, Vol. 157, Issue 12, pp. 4677-4690, (2016) (PubMed).

Li, Moore, Vasilieva, Sui, Wong, Berne, Somasundaran, Sullivan, Luzuriaga, Greenough, Choe, Farzan: "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus." in: Nature, Vol. 426, Issue 6965, pp. 450-4, (2003) (PubMed).

Crackower, Sarao, Oudit, Yagil, Kozieradzki, Scanga, Oliveira-dos-Santos, da Costa, Zhang, Pei, Scholey, Ferrario, Manoukian, Chappell, Backx, Yagil, Penninger: "Angiotensin-converting enzyme 2 is an essential regulator of heart function." in: Nature, Vol. 417, Issue 6891, pp. 822-8, (2002) (PubMed).

Donoghue, Hsieh, Baronas, Godbout, Gosselin, Stagliano, Donovan, Woolf, Robison, Jeyaseelan, Breitbart, Acton: "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9." in: Circulation research, Vol. 87, Issue 5, pp. E1-9, (2000) (PubMed).

Target Details for ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Alternative Name: ACE2 (ACE2 Products)

Synonyms: ACE1 antibody, CD143 antibody, DCP antibody, DCP1 antibody, ICH antibody, MVCD3 antibody, ACEH antibody, 2010305L05Rik antibody, zgc:92514 antibody, angiotensin I converting enzyme antibody, angiotensin I converting enzyme 2 antibody, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 antibody, ACE antibody, ACE2 antibody, Ace2 antibody, ace2 antibody

Gene ID: 59272

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour