BTK antibody (AA 209-239)

Catalog No. ABIN544377

Product Details anti-BTK Antibody

Target: BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))

Binding Specificity: AA 209-239

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTK antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of BTK.

Cross-Reactivity: Human

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to amino acids 209-239 at internal region of human BTK.

Application Details

Application Notes: Immunofluorescence (1:10-50)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-BTK antibody (ABIN544377)

Márquez, Smith, Petoukhov, Lo Surdo, Mattsson, Knekt, Westlund, Scheffzek, Saraste, Svergun: "Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering." in: The EMBO journal, Vol. 22, Issue 18, pp. 4616-24, (2003) (PubMed).

Jefferies, Doyle, Brunner, Dunne, Brint, Wietek, Walch, Wirth, ONeill: "Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 26258-64, (2003) (PubMed).

Horwood, Mahon, McDaid, Campbell, Mano, Brennan, Webster, Foxwell: "Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production." in: The Journal of experimental medicine, Vol. 197, Issue 12, pp. 1603-11, (2003) (PubMed).

Target Details for BTK

Target: BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))

Alternative Name: BTK (BTK Products)

Synonyms: BTK antibody, atk antibody, bpk antibody, xla antibody, imd1 antibody, agmx1 antibody, psctk1 antibody, AGMX1 antibody, AT antibody, ATK antibody, BPK antibody, IMD1 antibody, PSCTK1 antibody, XLA antibody, AI528679 antibody, xid antibody, Bruton tyrosine kinase antibody, Bruton agammaglobulinemia tyrosine kinase antibody, BTK antibody, btk antibody, Btk antibody

Gene ID: 695

Pathways: Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling