PDE10A antibody (N-Term)

Catalog No. ABIN5514456

This Rabbit Polyclonal antibody specifically detects PDE10A in WB. It exhibits reactivity toward Human, Rat, Dog, Horse and Rabbit.

Quick Overview for PDE10A antibody (N-Term) (ABIN5514456)

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Reactivity: Human, Rat, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE10A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE10A Antibody

Binding Specificity: N-Term

Purpose: PDE10A Antibody - N-terminal region

Sequence: SLHPQVLDEF VSESVSAETV EKWLKRKNNK SEDESAPKEV SRYQDTNMQG

Predicted Reactivity: Dog: 93%, Horse: 93%, Human: 100%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against PDE10A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PDE10A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP72732-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE10A

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Alternative Name: PDE10A

Background:

Background Information: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.

Alternative Symbols: ADSD2, IOLOD, HSPDE10A, PDE10A19, LINC00473

Molecular Weight: 85kDa

Gene ID: 10846

UniProt: Q9Y233

Pathways: cAMP Metabolic Process