CEP290 antibody (N-Term)

Catalog No. ABIN5514637

The Rabbit Polyclonal anti-CEP290 antibody is suitable to detect CEP290 in samples from Human. It has been validated for WB.

Quick Overview for CEP290 antibody (N-Term) (ABIN5514637)

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CEP290 Antibody

Binding Specificity: N-Term

Purpose: CEP290 Antibody - N-terminal region

Sequence: EQLCQDIIDY QKQIDSQKET LLSRRGEDSD YRSQLSKKNY ELIQYLDEIQ

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CEP290

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP80284-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290

Background:

Background Information: This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.

Gene Name: centrosomal protein 290 kDa

Alternative Symbols: CT87, MKS4, POC3, rd16, BBS14, JBTS5, LCA10, NPHP6, SLSN6, 3H11Ag

Protein Name: centrosomal protein of 290 kDa

Molecular Weight: 88 kDa

Gene ID: 80184

NCBI Accession: NP_079390

UniProt: Q05BJ6

Pathways: cAMP Metabolic Process, M Phase