Calpain 6 antibody (Middle Region)

Catalog No. ABIN5514668

Product Details anti-Calpain 6 Antibody

Target: Calpain 6 (CAPN6)

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain 6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TIPNHKEQEW DPQKTEKYAG IFHFRFWHFG EWTEVVIDDL LPTINGDLVF

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CAPN6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Calpain 6

Target: Calpain 6 (CAPN6)

Alternative Name: CAPN6 (CAPN6 Products)

Synonyms: CAPN6 antibody, CANPX antibody, CAPNX antibody, CalpM antibody, DJ914P14.1 antibody, calpain 6 antibody, CAPN6 antibody, Capn6 antibody

Background: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

Alias Symbols: CANPX, CAPNX, CalpM, DJ914P14.1

Protein Size: 641

Gene ID: 827

NCBI Accession: NM_014289, NP_055104

UniProt: Q9Y6Q1