ALIX antibody (C-Term)

Catalog No. ABIN5514748

The Rabbit Polyclonal anti-ALIX antibody is suitable to detect ALIX in samples from Human. It has been validated for WB.

Quick Overview for ALIX antibody (C-Term) (ABIN5514748)

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALIX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALIX Antibody

Binding Specificity: C-Term

Sequence: QMPMPMGYNP YAYGQYNMPY PPVYHQSPGQ APYPGPQQPS YPFPQPPQQS

Characteristics: This is a rabbit polyclonal antibody against PDC6I. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PDC6I

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Alternative Name: PDC6I

Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Alias Symbols: PDCD6IP, AIP1, ALIX, KIAA1375,

Protein Interaction Partner: UBI4, CEP55, UBC, SUMO2, nef, EZH2, IPO9, UBA6, MCTS1, AHCYL1, EZR, UBA1, MAPK1, CHMP4B, gag, UBD, BAG3, RNF11, KEAP1, VCAM1, SH3GL1, CHMP4C, TNIP2, ITGA4, CXCR1, GRB2, HOXA1, PEF1, VPS4B, ABCC1, GPI, PDCD6, F2R, CUL3, ALG2, PTK2B, TUBB, SIRT7, SH3KBP1, C

Protein Size: 868

Gene ID: 10015

NCBI Accession: NP_037506

UniProt: Q8WUM4

Pathways: p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation