Lamin A/C antibody (C-Term)

Catalog No. ABIN5514925

The Rabbit Polyclonal anti-Lamin A/C antibody has been validated for WB. It is suitable to detect Lamin A/C in samples from Human.

Quick Overview for Lamin A/C antibody (C-Term) (ABIN5514925)

Target: Lamin A/C (LMNA)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Lamin A/C Antibody

Binding Specificity: C-Term

Sequence: RTSGRVAVEE VDEEGKFVRL RNKSNEDQSM GNWQIKRQNG DDPLLTYRFP

Characteristics: This is a rabbit polyclonal antibody against LMNA. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human LMNA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: LMNA

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Alias Symbols: LMNA, LMN1,

Protein Interaction Partner: LMNA, RAPGEF2, FUS, KRTAP10-3, KRTAP10-7, DUSP13, UBC, TP53, SUMO2, SUMO3, MDM2, EED, KIAA0196, ROCK2, ZW10, NCL, EEF1D, PSMD10, GMPPB, KPNA6, KCTD12, PARK2, FBXO6, YWHAQ, ZNF280C, PGRMC2, SCML2, HNRNPR, TRIM28, ZBTB33, NUP153, THRAP3, USP15, POM121, DDX4

Protein Size: 664

Gene ID: 4000

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus