Translin antibody (Middle Region)

Catalog No. ABIN5515344

Product Details anti-Translin Antibody

Target: Translin (TSN)

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Translin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VNSVTAGDYS RPLHISTFIN ELDSGFRLLN LKNDSLRKRY DGLKYDVKKV

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TSN

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Translin

Target: Translin (TSN)

Alternative Name: TSN (TSN Products)

Synonyms: tsn antibody, MGC52533 antibody, TSN antibody, CG11761 antibody, Dmel\\CG11761 antibody, TB-RBP antibody, BCLF-1 antibody, C3PO antibody, RCHF1 antibody, REHF-1 antibody, TBRBP antibody, TRSLN antibody, 2610034C24Rik antibody, AU040286 antibody, translin L homeolog antibody, translin antibody, haloacid dehalogenase antibody, Translin antibody, tsn.L antibody, TSN antibody, trsn antibody, MMAH_RS03470 antibody, TAGG_RS05275 antibody, Igag_0962 antibody, MFER_RS03645 antibody, DESMU_RS01315 antibody, ARCVE_RS05265 antibody, MZHIL_RS01310 antibody, Tsn antibody

Background: This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants.

Alias Symbols: C3PO, RCHF1, TBRBP, TRSLN, BCLF-1, REHF-1

Protein Size: 228

Gene ID: 7247

NCBI Accession: NM_001261401, NP_001248330

UniProt: Q15631