EHD3 antibody (N-Term)

Catalog No. ABIN5516009

Product Details anti-EHD3 Antibody

Target: EHD3 (EH-Domain Containing 3 (EHD3))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EHD3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FSWLGTDDRR RKDPEVFQTV SEGLKKLYKS KLLPLEEHYR FHEFHSPALE

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EHD3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EHD3

Target: EHD3 (EH-Domain Containing 3 (EHD3))

Alternative Name: EHD3 (EHD3 Products)

Synonyms: PAST3 antibody, Ehd2 antibody, EHD3 antibody, si:ch211-147c1.2 antibody, MGC146452 antibody, EH domain containing 3 antibody, EH-domain containing 3 antibody, EH domain containing 3 L homeolog antibody, EHD3 antibody, Ehd3 antibody, ehd3 antibody, ehd3.L antibody

Background: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology. Involved in the recycling of internalized D1 dopamine receptor. Plays a role in cardiac protein trafficking probably implicating ANK. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction. In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function. Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis, possibly sharing redundant functions with EHD1.

Alias Symbols: PAST3

Protein Size: 535

Gene ID: 30845

NCBI Accession: NM_014600, NP_055415

UniProt: Q9NZN3