MAPK7 antibody (N-Term)

Catalog No. ABIN5516013

This Rabbit Polyclonal antibody specifically detects MAPK7 in WB. It exhibits reactivity toward Human.

Quick Overview for MAPK7 antibody (N-Term) (ABIN5516013)

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAPK7 Antibody

Binding Specificity: N-Term

Sequence: PLKEEDGEDG SAEPPGPVKA EPAHTAASVA AKNLALLKAR SFDVTFDVGD

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAPK7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAPK7

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Alternative Name: MAPK7

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

Alias Symbols: BMK1, ERK4, ERK5, PRKM7

Protein Size: 816

Gene ID: 5598

NCBI Accession: NM_002749, NP_002740

UniProt: Q13164

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling