MERTK antibody (N-Term)

Catalog No. ABIN5516110

The Rabbit Polyclonal anti-MERTK antibody is suitable to detect MERTK in samples from Human, Mouse, Rat, Cow, Rabbit, Dog, Horse and Pig. It has been validated for WB.

Quick Overview for MERTK antibody (N-Term) (ABIN5516110)

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MERTK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MERTK Antibody

Binding Specificity: N-Term

Purpose: MERTK Antibody - N-terminal region

Sequence: PEPVNIFWVQ NSSRVNEQPE KSPSVLTVPG LTEMAVFSCE AHNDKGLTVS

Predicted Reactivity: Cow: 79%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against MERTK. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MERTK

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59019-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Alternative Name: MERTK

Background:

Background Information: This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Gene Name: c-mer proto-oncogene tyrosine kinase

Alternative Symbols: MER, RP38, c-Eyk, c-mer, Tyro12

Protein Name: Tyrosine-protein kinase Mer

Molecular Weight: 109kDa

Gene ID: 10461

NCBI Accession: NP_006334

UniProt: Q12866

Pathways: RTK Signaling