CG4621 antibody, Dmel\\CG4621 antibody, dYL-1 antibody, vps72 antibody, MGC82727 antibody, Vps72 antibody, YL-1 antibody, ACYPI009531 antibody, Tcfl1 antibody, CFL1 antibody, Swc2 antibody, TCFL1 antibody, YL1 antibody, si:dkeyp-24a7.1 antibody, CG4621 gene product from transcript CG4621-RB antibody, vacuolar protein sorting 72 homolog L homeolog antibody, potential vacuolar protein sorting protein antibody, vacuolar protein sorting 72 homolog antibody, vacuolar protein sorting-associated protein 72 homolog antibody, vacuolar protein sorting 72 antibody, vacuolar protein sorting 72 homolog S homeolog antibody, vacuolar protein sorting 72 homolog (S. cerevisiae) antibody, YL-1 antibody, vps72.L antibody, VPS72 antibody, Vps72 antibody, vps72.S antibody, vps72 antibody
Background
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms.