TRF1 antibody (C-Term)

Catalog No. ABIN5516265

This Rabbit Polyclonal antibody specifically detects TRF1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Pig and Rabbit.

Quick Overview for TRF1 antibody (C-Term) (ABIN5516265)

Target: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRF1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRF1 Antibody

Binding Specificity: C-Term

Sequence: NLRSGVRKYG EGNWSKILLH YKFNNRTSVM LKDRWRTMKK LKLISSDSED

Predicted Reactivity: Cow: 91%, Dog: 91%, Horse: 91%, Human: 100%, Mouse: 90%, Pig: 91%, Rabbit: 82%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against TERF1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human TERF1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRF1

Target: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Alternative Name: TERF1

Background: This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.

Alias Symbols: TERF1, PIN2, TRBF1, TRF, TRF1,

Protein Interaction Partner: EP300, SKP1, UBC, ANXA8L1, FBXO4, U2AF1, U2AF2, KDM1A, TINF2, BTRC, TNKS, TCIRG1, SMAD9, BLM, ATM, TNKS2, PINX1, RLIM, DDX19B, PACSIN2, OGFR, TOMM34, WDR4, ARPP21, TRIM16, HEXIM1, PAICS, DNPH1, HMGN4, TUBB4B, TUBB3, AKR1A1, RTN3, PAK4, STUB1, DDX39A, DPP3

Protein Size: 439

Gene ID: 7013

NCBI Accession: NP_059523

UniProt: P54274

Pathways: Cell Division Cycle, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity