CRBN antibody (Middle Region)

Catalog No. ABIN5516299

The Rabbit Polyclonal anti-CRBN antibody has been validated for WB. It is suitable to detect CRBN in samples from Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Dog.

Quick Overview for CRBN antibody (Middle Region) (ABIN5516299)

Target: CRBN (Cereblon (CRBN))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRBN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CRBN Antibody

Binding Specificity: Middle Region

Sequence: GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA KVQILPECVL PSTMSAVQLE

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against CRBN. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human CRBN

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CRBN

Target: CRBN (Cereblon (CRBN))

Alternative Name: CRBN

Background: This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: CRBN, AD-006,

Protein Interaction Partner: PAK7, RBPMS, MEIS2, DDB1, IKZF3, IKZF1, SUV39H1, KDM1A, UBC, COPS4, COPS6, COPS3, PSMB4, PSMA2, COPS5, CUL4A, PRKAA1, RBX1,

Protein Size: 442

Gene ID: 51185

NCBI Accession: NP_057386

UniProt: Q96SW2