GLRB antibody (N-Term)

Catalog No. ABIN5516877

This Rabbit Polyclonal antibody specifically detects GLRB in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Pig, Dog, Rabbit, Guinea Pig and Horse.

Quick Overview for GLRB antibody (N-Term) (ABIN5516877)

Target: GLRB (Glycine Receptor, beta (GLRB))

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLRB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GLRB Antibody

Binding Specificity: N-Term

Purpose: GLRB Antibody - N-terminal region

Sequence: LLTTAFLILI SLWVEEAYSK EKSSKKGKGK KKQYLCPSQQ SAEDLARVPA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against GLRB. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GLRB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP34996-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GLRB

Target: GLRB (Glycine Receptor, beta (GLRB))

Alternative Name: GLRB

Background:

Background Information: This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

Gene Name: glycine receptor, beta

Alternative Symbols: HKPX2

Protein Name: Glycine receptor subunit beta

Molecular Weight: 54kDa

Gene ID: 2743

UniProt: P48167