GSTM4 antibody (Middle Region)

Catalog No. ABIN5516880

Product Details anti-GSTM4 Antibody

Target: GSTM4 (Glutathione S-Transferase mu 4 (GSTM4))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTM4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EYTDSSYEEK KYTMGDAPDY DRSQWLNEKF KLGLDFPNLP YLIDGAHKIT

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GSTM4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GSTM4

Target: GSTM4 (Glutathione S-Transferase mu 4 (GSTM4))

Alternative Name: GSTM4 (GSTM4 Products)

Synonyms: GSTM4-4 antibody, GTM4 antibody, 1110004G14Rik antibody, GSTM7-7 antibody, Gstb-4 antibody, Gstb4 antibody, glutathione S-transferase mu 4 antibody, glutathione S-transferase, mu 4 antibody, GSTM4 antibody, Gstm4 antibody

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.

Alias Symbols: GTM4, GSTM4-4,

Protein Size: 218

Gene ID: 2948

NCBI Accession: NM_000850, NP_000841

UniProt: Q03013