MCM6 antibody (Middle Region)

Catalog No. ABIN5517110

The Rabbit Polyclonal anti-MCM6 antibody (ABIN5517110) specifically detects MCM6 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Guinea Pig, Cow, Horse, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for MCM6 antibody (Middle Region) (ABIN5517110)

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Cow, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MCM6 Antibody

Binding Specificity: Middle Region

Sequence: CVAPTNPRFG GKELRDEEQT AESIKNQMTV KEWEKVFEMS QDKNLYHNLC

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against MCM6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human MCM6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MCM6

Target: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Alternative Name: MCM6

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.

Alias Symbols: MCM6,

Protein Interaction Partner: MCM10, HUWE1, SNRPB2, MCM2, NUDT2, ZBTB9, FAM161A, UBC, SUMO2, SUMO3, MCMBP, POLK, MCM4, MCM3, KPNA3, HSP90AB1, CDKN2A, ACLY, CAP1, ING5, MCM6, BAG3, TONSL, MMS22L, ASF1B, SMC1A, MCM7, CCNA1, VCAM1, ITGA4, FN1, gag-pol, GMNN, ORC6, DBF4, CDC7, PAXIP1, TP5

Protein Size: 821

Gene ID: 4175

UniProt: Q14566

Pathways: DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA