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MCM6 antibody (Middle Region)
MCM6
Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MCM6 Antibody
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Target
See all MCM6 Antibodies
MCM6
(Minichromosome Maintenance Complex Component 6 (MCM6))
Binding Specificity
All epitopes for MCM6 antibodies
Middle Region
Reactivity
All reactivities for MCM6 antibodies
Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)
Host
All hosts for MCM6 antibodies
Rabbit
Clonality
All clonalities for MCM6 antibodies
Polyclonal
Conjugate
All conjugates for MCM6 antibodies
This MCM6 antibody is un-conjugated
Application
All applications for MCM6 antibodies
Western Blotting (WB)
Sequence
CVAPTNPRFG GKELRDEEQT AESIKNQMTV KEWEKVFEMS QDKNLYHNLC
Predicted Reactivity
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
Characteristics
This is a rabbit polyclonal antibody against MCM6. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human MCM6
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for MCM6
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Target
MCM6
(Minichromosome Maintenance Complex Component 6 (MCM6))
Alternative Name
MCM6 (MCM6 Products )
Synonyms
CG4039 antibody, DmMCM6 antibody, DmeMCM6 antibody, Dmel\\CG4039 antibody, MCM6 antibody, McM6 antibody, fs(1)K1214 antibody, mcm6 antibody, MCG40308 antibody, Mis5 antibody, P105MCM antibody, Mcmd6 antibody, mis5 antibody, mmcm6 antibody, ASP-l1 antibody, D1Wsu22e antibody, Minichromosome maintenance 6 antibody, DNA replication licensing factor MCM6 antibody, minichromosome maintenance complex component 6 antibody, minichromosome maintenance complex component 6 L homeolog antibody, DNA replication licensing factor mcm-6 antibody, Mcm6 antibody, TP02_0113 antibody, PVX_114735 antibody, CMU_027970 antibody, MCM6 antibody, mcm6.L antibody, mcm-6 antibody
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. Alias Symbols: MCM6, Protein Interaction Partner: MCM10, HUWE1, SNRPB2, MCM2, NUDT2, ZBTB9, FAM161A, UBC, SUMO2, SUMO3, MCMBP, POLK, MCM4, MCM3, KPNA3, HSP90AB1, CDKN2A, ACLY, CAP1, ING5, MCM6, BAG3, TONSL, MMS22L, ASF1B, SMC1A, MCM7, CCNA1, VCAM1, ITGA4, FN1, gag-pol, GMNN, ORC6, DBF4, CDC7, PAXIP1, TP5 Protein Size: 821
Gene ID
4175
UniProt
Q14566
Pathways
DNA Damage Repair , Mitotic G1-G1/S Phases , DNA Replication , Synthesis of DNA
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