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Phospholipase C gamma 1 antibody (C-Term)
PLCG1
Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Phospholipase C gamma 1 Antibody
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Target
See all Phospholipase C gamma 1 (PLCG1) Antibodies
Phospholipase C gamma 1 (PLCG1)
(phospholipase C, gamma 1 (PLCG1))
Binding Specificity
All epitopes for Phospholipase C gamma 1 antibodies
C-Term
Reactivity
All reactivities for Phospholipase C gamma 1 antibodies
Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig
Host
All hosts for Phospholipase C gamma 1 antibodies
Rabbit
Clonality
All clonalities for Phospholipase C gamma 1 antibodies
Polyclonal
Conjugate
All conjugates for Phospholipase C gamma 1 antibodies
This Phospholipase C gamma 1 antibody is un-conjugated
Application
All applications for Phospholipase C gamma 1 antibodies
Western Blotting (WB)
Sequence
RGIVCPFVEI EVAGAEYDST KQKTEFVVDN GLNPVWPAKP FHFQISNPEF
Predicted Reactivity
Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Characteristics
This is a rabbit polyclonal antibody against PLCG1. It was validated on Western Blot.
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLCG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for Phospholipase C gamma 1
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Target
Phospholipase C gamma 1 (PLCG1)
(phospholipase C, gamma 1 (PLCG1))
Alternative Name
PLCG1 (PLCG1 Products )
Synonyms
NCKAP3 antibody, PLC-II antibody, PLC1 antibody, PLC148 antibody, PLCgamma1 antibody, plc1 antibody, nckap3 antibody, plc-ii antibody, plc148 antibody, plcgamma1 antibody, PPLCA antibody, AI894140 antibody, Cded antibody, Plc-1 antibody, Plc-gamma1 antibody, Plcg-1 antibody, fj46f04 antibody, wu:fj46f04 antibody, wu:fj57a05 antibody, phospholipase C gamma 1 antibody, phospholipase C gamma 1 L homeolog antibody, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 antibody, phospholipase C, gamma 1 antibody, PLCG1 antibody, plcg1.L antibody, LOC100633163 antibody, Plcg1 antibody, plcg1 antibody
Background
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. Alias Symbols: PLC1 Protein Interaction Partner: EGFR, UBC, SARNP, WDR61, RIC8A, AASDHPPT, UBR7, EHD4, DPP7, GTF3C4, LIMD1, RPL38, PYGB, ZAP70, KHDRBS1, RASA1, JAK2, JAK1, LCP2, ERBB3, ERBB2, CBL, LAT, VAV1, PDGFRB, INSR, IRS2, NTMT1, SPRY1, NPM1, NCAM1, ALK, PML, IBTK, EEF1A1, BLNK, BAG3, EPOR, CAMK2A, Protein Size: 1290
Gene ID
5335
UniProt
P19174
Pathways
RTK Signaling , WNT Signaling , TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Thyroid Hormone Synthesis , Inositol Metabolic Process , Myometrial Relaxation and Contraction , Regulation of Muscle Cell Differentiation , Regulation of G-Protein Coupled Receptor Protein Signaling , Skeletal Muscle Fiber Development , G-protein mediated Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Interaction of EGFR with phospholipase C-gamma , VEGFR1 Specific Signals , VEGF Signaling
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