UBXN8 antibody (Middle Region)

Catalog No. ABIN5517391

Product Details anti-UBXN8 Antibody

Target: UBXN8 (UBX Domain Protein 8 (UBXN8))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBXN8 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RKLEERFYQM TGEAWKLSSG HKLGGDEGTS QTSFETSNRE AAKSQNLPKP

Characteristics: This is a rabbit polyclonal antibody against UBXN8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human UBXN8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for UBXN8

Target: UBXN8 (UBX Domain Protein 8 (UBXN8))

Alternative Name: UBXN8 (UBXN8 Products)

Synonyms: D8S2298E antibody, REP8 antibody, UBXD6 antibody, D0H8S2298E antibody, Rep-8 antibody, Rep8h antibody, Ubxd6 antibody, UBX domain protein 8 antibody, UBXN8 antibody, Ubxn8 antibody

Background: P97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: UBXN8, D8S2298E, REP8, UBXD6,

Protein Interaction Partner: UBC, ADRB2, SYVN1, VCP, VCPIP1, NPLOC4, UFD1L,

Protein Size: 270

Gene ID: 7993

NCBI Accession: NP_005662

UniProt: O00124

Pathways: SARS-CoV-2 Protein Interactome