MC1 Receptor antibody (N-Term)

Catalog No. ABIN5517430

The Rabbit Polyclonal anti-MC1 Receptor antibody is suitable to detect MC1 Receptor in samples from Human. It has been validated for WB.

Quick Overview for MC1 Receptor antibody (N-Term) (ABIN5517430)

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MC1 Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MC1 Receptor Antibody

Binding Specificity: N-Term

Sequence: QRRLLGSLNS TPTAIPQLGL AANQTGARCL EVSISDGLFL SLGLVSLVEN

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MC1R

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Alternative Name: MC1R

Background: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Alias Symbols: CMM5, MSH-R, SHEP2

Protein Size: 317

Gene ID: 4157

NCBI Accession: NM_002386, NP_002377

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour