MBTPS2 antibody (N-Term)

Catalog No. ABIN5517527

Product Details anti-MBTPS2 Antibody

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBTPS2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VGGWTVVYLT DLVLKSSVYF KHSYEDWLEN NGLSISPFHI RWQTAVFNRA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MBTPS2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MBTPS2

Target: MBTPS2 (Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2))

Alternative Name: MBTPS2 (MBTPS2 Products)

Synonyms: BRESEK antibody, IFAP antibody, KFSDX antibody, S2P antibody, 9630032G22Rik antibody, AI662535 antibody, LRRGT00063 antibody, membrane bound transcription factor peptidase, site 2 antibody, membrane-bound transcription factor peptidase, site 2 antibody, MBTPS2 antibody, Mbtps2 antibody

Background: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome), IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

Alias Symbols: S2P, IFAP, KFSD, KFSDX, OLMSX, BRESEK

Protein Interaction Partner: UBC, ATF6B,

Protein Size: 519

Gene ID: 51360

NCBI Accession: NM_015884, NP_056968

UniProt: O43462

Pathways: ER-Nucleus Signaling