FLT3LG antibody (AA 28-189)

Catalog No. ABIN5518989

Product Details anti-FLT3LG Antibody

Target: FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))

Binding Specificity: AA 28-189

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLT3LG antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Rabbit IgG polyclonal antibody for Flt3 ligand detection. Tested with WB, Direct ELISA in Mouse,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Flt3 ligand detection. Tested with WB, Direct ELISA in Mouse,Rat.
Gene Name: fms related tyrosine kinase 3 ligand
Protein Name: Fms-related tyrosine kinase 3 ligand

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse Flt3 ligand recombinant protein (Position: T28-Q189).

Isotype: IgG

Application Details

Application Notes: Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for FLT3LG

Target: FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))

Alternative Name: Flt3lg (FLT3LG Products)

Synonyms: Flt3lg antibody, Ly72L antibody, FL antibody, FLT3L antibody, Vegfr3 antibody, fms related tyrosine kinase 3 ligand antibody, FMS-like tyrosine kinase 3 ligand antibody, fms-related tyrosine kinase 4 antibody, fms-related tyrosine kinase 3 ligand antibody, FLT3LG antibody, Flt3l antibody, Flt4 antibody, Flt3lg antibody

Background: FLT3LG (FMS-Related Tyrosine Kinase 3 Ligand) also called FLT3 LIGAND, FL or FLT3L, is a protein which in humans is encoded by the FLT3LG gene. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8-positive classical DCs and their CD103-positive tissue counterparts. Flt3 ligand (FL) is a hematopoietic four helical bundlecytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. Lyman et al. (1993) found that Flt3 ligand stimulated proliferation of hematopoietic progenitor cells isolated from mouse fetal liver or adult mouse bone marrow. Hannum et al. (1994) concluded that FL enhances the response of stem and primitive progenitor cells to other growth factors to generate all myeloid lineages except erythroid cells. Assays of C-terminally truncated FL proteins confirmed that the N-terminal half conferred FL activity. Depletion of the Pi3k -Mtor negative regulator Pten facilitated Flt3l-driven DC development in culture.

Synonyms: Fms-related tyrosine kinase 3 ligand, Flt3 ligand, Flt3L, SL cytokine, Flt3lg, Flt3l

Gene ID: 2323

UniProt: P49772

Pathways: RTK Signaling