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Neuregulin 1 antibody (AA 198-229)

NRG1 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5531711
  • Target See all Neuregulin 1 (NRG1) Antibodies
    Neuregulin 1 (NRG1)
    Binding Specificity
    • 16
    • 16
    • 15
    • 10
    • 10
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 198-229
    Reactivity
    • 103
    • 77
    • 53
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 121
    • 10
    Rabbit
    Clonality
    • 121
    • 10
    Polyclonal
    Conjugate
    • 58
    • 13
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    This Neuregulin 1 antibody is un-conjugated
    Application
    • 92
    • 43
    • 39
    • 39
    • 39
    • 37
    • 24
    • 14
    • 12
    • 11
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogen
    This NRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-229 amino acids from the Central region of human NRG1.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product NRG1 Primary Antibody
  • Application Notes
    For WB starting dilution is: 1:1000

    For FACS starting dilution is: 1:10~50

    For IHC-P starting dilution is: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.79 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    Neuregulin 1 (NRG1)
    Alternative Name
    NRG1 (NRG1 Products)
    Synonyms
    6030402G23Rik antibody, ARIA antibody, D230005F13Rik antibody, GGF antibody, GGFII antibody, HRG antibody, HRGalpha antibody, Hgl antibody, NDF antibody, SMDF antibody, GGF2 antibody, HGL antibody, HRG1 antibody, HRGA antibody, MST131 antibody, NRG-1 antibody, heregulin antibody, nrg1-A antibody, pro-neuregulin-1 antibody, NRG1 antibody, wu:fm70e01 antibody, DKFZp459A1838 antibody, neuregulin 1 antibody, histidine rich glycoprotein antibody, neuregulin 1 L homeolog antibody, Nrg1 antibody, NRG1 antibody, HRG antibody, nrg1.L antibody, nrg1 antibody
    Background
    Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
    Molecular Weight
    70 kDa
    Gene ID
    3084
    UniProt
    Q02297
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
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