SSRP1 antibody (C-Term)

Catalog No. ABIN5533212

The Rabbit Polyclonal anti-SSRP1 antibody is suitable to detect SSRP1 in samples from Human. It has been validated for WB.

Quick Overview for SSRP1 antibody (C-Term) (ABIN5533212)

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSRP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SSRP1 Antibody

Binding Specificity: AA 490-518, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SSRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the C-terminal region of human SSRP1.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SSRP1

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Alternative Name: SSRP1

Background: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.

Molecular Weight: 81 kDa

Gene ID: 6749

UniProt: Q08945

Pathways: Chromatin Binding