MYH7 antibody (N-Term)

Catalog No. ABIN5533275

Product Details anti-MYH7 Antibody

Target: MYH7 (Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7))

Binding Specificity: AA 185-211, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYH7 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MYH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the N-terminal region of human MYH7.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for MYH7

Target: MYH7 (Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7))

Alternative Name: MYH7 (MYH7 Products)

Synonyms: CMD1S antibody, CMH1 antibody, MPD1 antibody, MYHCB antibody, SPMD antibody, SPMM antibody, Myhcb antibody, AMHC1 antibody, myosin antibody, myosin-7 antibody, B-MHC antibody, MyHC-I antibody, Myhc-b antibody, beta-MHC antibody, myosin heavy chain 7 antibody, myosin, heavy chain 7, cardiac muscle, beta antibody, myosin, heavy polypeptide 7, cardiac muscle, beta antibody, MYH7 antibody, Myh7 antibody

Background: Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Molecular Weight: 223 kDa

Gene ID: 4625

UniProt: P12883