PSMD10 antibody (AA 43-76)

Catalog No. ABIN5536458

Product Details anti-PSMD10 Antibody

Target: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Binding Specificity: AA 43-76

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD10 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PSMD10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 43-76 amino acids from the Central region of human PSMD10.

Isotype: Ig Fraction

Application Details

Application Notes: For IF starting dilution is: 1:25

For IHC-P starting dilution is: 1:25

For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.48 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PSMD10

Target: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Alternative Name: PSMD10 (PSMD10 Products)

Synonyms: gankyrin antibody, zgc:109707 antibody, dJ889N15.2 antibody, p28 antibody, p28(GANK) antibody, AW554874 antibody, p28Gank antibody, proteasome 26S subunit, non-ATPase 10 antibody, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 antibody, psmd10 antibody, PSMD10 antibody, Psmd10 antibody

Background: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.

Molecular Weight: 24 kDa

Gene ID: 5716

UniProt: O75832

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway