RGL4 antibody (N-Term)

Catalog No. ABIN5538799

Product Details anti-RGL4 Antibody

Target: RGL4 (Ral Guanine Nucleotide Dissociation Stimulator-Like 4 (RGL4))

Binding Specificity: AA 98-125, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGL4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RGL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-125 amino acids from the N-terminal region of human RGL4.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RGL4

Target: RGL4 (Ral Guanine Nucleotide Dissociation Stimulator-Like 4 (RGL4))

Alternative Name: RGL4 (RGL4 Products)

Synonyms: Rgr antibody, ral guanine nucleotide dissociation stimulator like 4 antibody, RGL4 antibody

Background: Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL4 (ral guanine nucleotide dissociation stimulator-like 4), also known as Rgr, is a 473 amino acid protein that localizes to the cytoplasmic vesicle of cells. Belonging to the GEF family of proteins, RGL4 induces phosphorylation of ERKs, p38 and JNK kinases, and it increases the levels of GTP bound forms of Ral and Ras. Ras activation is crucial for the transforming activity of RGL4. Due to its similarity to Ral GDS, RGL4 may be implicated in carcinogenesis.

Molecular Weight: 52 kDa

Gene ID: 266747

UniProt: Q8IZJ4