FPR2 antibody (2nd Extracellular Loop)

Catalog No. ABIN5540339

This Rabbit Polyclonal antibody specifically detects FPR2 in WB, FACS, IF and ICC. It exhibits reactivity toward Human.

Quick Overview for FPR2 antibody (2nd Extracellular Loop) (ABIN5540339)

Target: FPR2 (Formyl Peptide Receptor 2 (FPR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FPR2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-FPR2 Antibody

Binding Specificity: 2nd Extracellular Loop

Sequence: ASWGGTPEER LKC

Specificity: This antibody recognizes a 38 kDa Human FPRL-1.

Purification: Affinity Chromatography on Protein G

Immunogen: A short peptide corresponding to the amino acids on the 2nd extracellular loop of Human FPRL1

Application Details

Application Notes: Western blot: 1/4000-1/5000. Immunofluorescence: 1/400-1/500. Flow Cytometry: 1/100 using HL-60 as positive control .

Restrictions: For Research Use only

Handling

Buffer: 0.01M PBS, pH 7.2

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for FPR2

Target: FPR2 (Formyl Peptide Receptor 2 (FPR2))

Alternative Name: fpr2,fprl1

Background: Human formyl peptide receptor-like 1(FPRL1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-α by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer's disease.