GDF15 antibody (N-Term)

Catalog No. ABIN5540380

The Mouse Monoclonal anti-GDF15 antibody (Clone ME-6D10) (ABIN5540380) specifically detects GDF15 in FACS and EIA. The antibody is reactive with Human samples.

Quick Overview for GDF15 antibody (N-Term) (ABIN5540380)

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GDF15 antibody is un-conjugated

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: ME-6D10

Product Details anti-GDF15 Antibody

Binding Specificity: AA 30-194, N-Term

Specificity: Recognizes Human Macrophage Inhibitory Cytokine-1 (MIC-1). Other species not tested.

Purification: Affinity Chromatography on Protein G

Immunogen: Genetic immunisation with cDNA encoding amino acids 30-194 (N-term) of MIC-1 proprotein.

Isotype: IgG1

Application Details

Application Notes: Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow Cytometry: 1.2 μg/10 6 cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate buffered saline, pH 7.2 without preservatives

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for GDF15

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Alternative Name: gdf15

Background: Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-ß superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance (1). MIC-1 is synthesized as a 62- kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25- kDa disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines (1,2). MIC-1 is involved in tumour pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumours (3).

UniProt: Q99988

Pathways: SARS-CoV-2 Protein Interactome