GDNF antibody

Catalog No. ABIN5540934

There is 1 publication for this product available. The Mouse Monoclonal anti-GDNF antibody is suitable to detect GDNF in samples from Human. It has been validated for WB, ICC, IHC (p), IF and EIA.

Quick Overview for GDNF antibody (ABIN5540934)

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GDNF antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Clone: 3C1

Product Details anti-GDNF Antibody

Specificity: Recognizes Human GDNF. Other species not tested.

Purification: Affinity Chromatography on Protein G

Immunogen: Recombinant human GDNF protein produced using E. coli expression system.

Isotype: IgG1

Application Details

Application Notes: ELISA: 50-100 ng/mL. Western Blot: 2-5 μg/mL. Immunofluorescence: 2-10 μg/mL. Immunohistochemistry on Paraffin Sections: 5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.4 Preservatives: 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store (in aliquots) at -20°C to -80°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

References for anti-GDNF antibody (ABIN5540934)

Lin, Hsieh, Chen, Wu, Tsai, Huang, Hua, Wei, Yeh, Liu: "Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 235, pp. 72-81, (2016) (PubMed).

Target Details for GDNF

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Alternative Name: gdnf

Background: GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex.

UniProt: P39905

Pathways: RTK Signaling, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration