PAI1 antibody

Catalog No. ABIN5541683

This Mouse Monoclonal antibody specifically detects PAI1 in WB, FACS, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for PAI1 antibody (ABIN5541683)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAI1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 1D5

Product Details anti-PAI1 Antibody

Specificity: This antibody recognizes Human SERPINE1 / PAI-1. Other species not tested.

Purification: Purified

Immunogen: Purified recombinant fragment of Human SERPINE1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA : 1/10000. Western Blot: 1/500-1/2000. Flow Cytometry: 1/200-1/400. Immunohistochemistry on Paraffin Sections : 1/200-1/1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.05 % Sodium Azide Stabilizers: 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Alternative Name: serpine1,pai1

Background: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt: P05121

Pathways: p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration