Staphylococcus Aureus Enterotoxin Type B antibody

Catalog No. ABIN5542128

Product Details anti-Staphylococcus Aureus Enterotoxin Type B Antibody

Target: Staphylococcus Aureus Enterotoxin Type B

Reactivity: Staphylococcus aureus

Host: Mouse

Clonality: Monoclonal

Conjugate: This Staphylococcus Aureus Enterotoxin Type B antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Specificity: Staphylococcal Enterotoxin B (SEB).

Purification: Affinity Chromatography on Protein G

Immunogen: SEB purified from Staphylococcus aureus.

Clone: SEB

Isotype: IgG1

Application Details

Application Notes: ELISA. This Staphylococcal Enterotoxin B (Clone SEB) as a superantigen for T-lymphocytes is a potential targeting antigen in cancer immunotherapy. It has been suggested that monoclonal antibody to SEB has been useful in immunotherapy research.

Restrictions: For Research Use only

Handling

Buffer: 0.01M PBS, pH 7.2 without preservatives

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Staphylococcus Aureus Enterotoxin Type B

Target: Staphylococcus Aureus Enterotoxin Type B

Alternative Name: staphylococcus aureus enterotoxin b (Staphylococcus Aureus Enterotoxin Type B Products)

Background: Staphylococcal enterotoxin B (SEB) is an enterotoxin secreted by Staphylococcus aureus. The bacterium thrives on meet, baking and dairy products and also colonizes in host nasal passageway. Ingestion of SEB contaminated food is the common cause of "food poisoning", manifested by flu-like symptoms, vomiting, diarrhea and intestinal cramps. In severe cases, SEB can cause respiratory failure and systemic toxic shock. These symptoms are the results of increased membrane permeability and abnormal activation of Tlymphocytes by SEB. SEB acts as a superantigen by binding directly to major histocompatibility complex class II (MHCII) on antigen presenting cells, thus, causing massive CD4 and CD8 Tcells activation and cytokine production. If unchecked, the process can result in systemic organ failure and death.

UniProt: P01552