HSD17B1 antibody (AA 189-285)

Catalog No. ABIN561371

There are 3+ publications for this product available. The Mouse Monoclonal anti-HSD17B1 antibody is suitable to detect HSD17B1 in samples from Human. It has been validated for WB, ELISA and IHC (p).

Quick Overview for HSD17B1 antibody (AA 189-285) (ABIN561371)

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSD17B1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2E5

Product Details anti-HSD17B1 Antibody

Binding Specificity: AA 189-285

Purpose: Mouse monoclonal antibody raised against a partial recombinant HSD17B1.

Sequence: VHTAFMEKVL GSPEEVLDRT DIHTFHRFYQ YLAHSKQVFR EAAQNPEEVA EVFLTALRAP KPTLRYFTTE RFLPLLRMRL DDPSGSNYVT AMHREVF

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: HSD17B1 (NP_000404, 189 a.a. ~ 285 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-HSD17B1 antibody (ABIN561371)

McNamara, Oguro, Omata, Kikuchi, Guestini, Suzuki, Yang, Abe, Hirakawa, Brown, Takanori, Ohuchi, Sasano: "The presence and impact of estrogen metabolism on the biology of triple-negative breast cancer." in: Breast cancer research and treatment, Vol. 161, Issue 2, pp. 213-227, (2016) (PubMed).

Inoue, Miki, Abe, Hatori, Hosaka, Kariya, Kakuo, Fujimura, Hachiya, Aiba, Sasano: "The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis." in: Molecular and cellular endocrinology, Vol. 344, Issue 1-2, pp. 35-40, (2011) (PubMed).

Chanplakorn, Chanplakorn, Suzuki, Ono, Chan, Miki, Saji, Ueno, Toi, Sasano: "Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients." in: Breast cancer research and treatment, Vol. 120, Issue 3, pp. 639-48, (2010) (PubMed).

Target Details for HSD17B1

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Alternative Name: HSD17B1

Background: Full Gene Name: hydroxysteroid (17-beta) dehydrogenase 1
Synonyms: EDH17B2,EDHB17,HSD17,MGC138140,SDR28C1

Gene ID: 3292

NCBI Accession: NM_000413

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis