NPM1 antibody (AA 1-294)
Quick Overview for NPM1 antibody (AA 1-294) (ABIN562035)
Target
See all NPM1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Binding Specificity
- AA 1-294
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Purpose
- Mouse monoclonal antibody raised against a full length recombinant NPM1.
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Sequence
- MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL
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Cross-Reactivity
- Human
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Characteristics
- Antibody Reactive Against Recombinant Protein.
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Immunogen
- NPM1 (AAH02398.1, 1 a.a. ~ 294 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Isotype
- IgG1
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Buffer
- In 1x PBS, pH 7.4
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Handling Advice
- Aliquot to avoid repeated freezing and thawing.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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: "Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells." in: Blood, Vol. 125, Issue 22, pp. 3447-54, (2015) (PubMed).
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- NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))
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Alternative Name
- NPM1
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Background
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Full Gene Name: nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Synonyms: B23,MGC104254,NPM -
Gene ID
- 4869
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Pathways
- Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Target
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