CHD5 antibody (AA 64-98)

Catalog No. ABIN5647082

Product Details anti-CHD5 Antibody

Target: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Binding Specificity: AA 64-98

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHD5 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 64-98 from the human protein was used as the immunogen for the CHD5 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Western blot: 1:1000-2000

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CHD5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for CHD5

Target: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Alternative Name: CHD5 / Chromodomain-helicase-DNA-binding protein 5 (CHD5 Products)

Synonyms: CHD-5 antibody, 4930532L22Rik antibody, AW060752 antibody, B230399N07Rik antibody, CHD5 antibody, chromodomain helicase DNA binding protein 5 antibody, potassium voltage-gated channel subfamily A regulatory beta subunit 2 antibody, CHD5 antibody, Chd5 antibody, chd5 antibody, KCNAB2 antibody

Background: Chromodomain-helicase-DNA-binding protein 5 is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

Gene ID: 26038

UniProt: Q8TDI0