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Isocitrate Dehydrogenase antibody (Biotin)

IDH Reactivity: Pig WB, IF, IP, EIA, DB, ID, RIA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN568271
  • Target See all Isocitrate Dehydrogenase (IDH) Antibodies
    Isocitrate Dehydrogenase (IDH)
    Reactivity
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Pig
    Host
    • 12
    • 1
    Rabbit
    Clonality
    • 13
    Polyclonal
    Conjugate
    • 9
    • 3
    • 1
    This Isocitrate Dehydrogenase antibody is conjugated to Biotin
    Application
    • 13
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Dot Blot (DB), Immunodiffusion (ID), Radioimmunoassay (RIA)
    Characteristics
    Molar Ratio: Biotin/IgG ~6.5
    Purification
    Ammonium Sulphate Precipitation and Ion Exchange Chromatography
    Immunogen
    Isocitrate Dehydrogenase isolated and purified from Porcine heart. Freund’s complete adjuvant is used in the first step of the immunization procedure.
    Isotype
    IgG
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    Discover our top product IDH Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    Restore by adding 1.0 mL sterile distilled water
    Concentration
    10 mg/mL
    Buffer
    PBS, pH 7.2 without preservatives and foreign proteins
    Preservative
    Without preservative
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody lyophilized at 2-8 °C and reconstituted at 2-8 °C for one week or (in aliquots) at -20 °C for longer. If a slight precipitation occurs upon storage, this should be removed by centrifugation.
  • Target
    Isocitrate Dehydrogenase (IDH)
    Alternative Name
    Isocitrate Dehydrogenase / IDH (IDH Products)
    Synonyms
    CG7176 antibody, CT22171 antibody, Dmel\\CG7176 antibody, IDH antibody, IDH-NADP antibody, Idh-NADP antibody, idh antibody, isocitrate dehydrogenase antibody, l(3)L3852 antibody, F20D21.16 antibody, F20D21_16 antibody, SMU.672 antibody, icd antibody, Isocitrate dehydrogenase antibody, isocitrate dehydrogenase antibody, isocitrate dehydrogenase, NADP-dependent antibody, Monomeric isocitrate dehydrogenase antibody, ankyrin repeat domain 26-like antibody, Idh antibody, ICDH antibody, idh antibody, icd antibody, SSO_RS10660 antibody, JK_RS08640 antibody, LOC618625 antibody
    Background
    Isocitrate dehydrogenase is an enzyme involved in the citric acid cycle. It is 416 amino acids long with a molecular weight of approximately 45 kDa. Isocitrate dehydrogenase enzymes catalyze the oxidative decarboxylation of isocitrate to produce alfa ketoglutarate. The human genome has 5 IDH genes coding for 3 IDH enzymes. The IDH1 and IDH2 require nicotinamide adeninedinucleotide phosphate (NADP) as co-substrate, whereas IDH3 require nicotinamide adenine dinucleotide (NAD). The IDH2 and 3 are localized in mitochondria and are actively involved in the citric acid cycle (TCA) for energy production in contrast, IDH1 is localized in cytoplasm and peroxisomes where it generates NADPH, reduced form of NADP for biosynthetic and other types of reaction. Since alfa KG and NADPH both are intermediately substrate for a number of cellular process, which allows the possibility of oncogenic or tumor suppressive activities of IDH1.Synonyms: Cytosolic NADP-isocitrate dehydrogenase, ICDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD, cytoplasmic Isocitrate dehydrogenase [NADP]
    Gene ID
    9823
    UniProt
    P20304
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