FOXO4 antibody (AA 195-199)

Catalog No. ABIN5689227

This Rabbit Polyclonal antibody specifically detects FOXO4 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FOXO4 antibody (AA 195-199) (ABIN5689227)

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXO4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FOXO4 Antibody

Binding Specificity: AA 195-199

Specificity: This antibody detects endogenous level of total AFX protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: AFX (Ab-197) antibody was raised against a peptide sequence around aa. 195~199 (A-A-S-M-D) derived from Human AFX.

Application Details

Application Notes: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for FOXO4

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Alternative Name: AFX

Background: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.

Molecular Weight: 65 kDa

Gene ID: 4303

NCBI Accession: NP_001164402

UniProt: P98177

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation