DAP antibody (C-Term)

Catalog No. ABIN5689938

Product Details anti-DAP Antibody

Target: DAP (Death-Associated Protein (DAP))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAP antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: DAP antibody is human, mouse and rat reactive.

Purification: DAP Antibody is affinity chromatography purified via peptide column.

Immunogen: DAP antibody was raised against a 19 amino acid peptide near the carboxy terminus of human DAP.

The immunogen is located within the last 50 amino acids of DAP.

Isotype: IgG

Application Details

Application Notes: DAP antibody can be used for detection of DAP by Western blot at 1 - 2 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DAP Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: DAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for DAP

Target: DAP (Death-Associated Protein (DAP))

Alternative Name: DAP (DAP Products)

Synonyms: Rap7a antibody, 4921531N22Rik antibody, AI789753 antibody, AU040360 antibody, MGC53808 antibody, MGC85522 antibody, DAP1 antibody, DAP antibody, Dap antibody, ACYPI007535 antibody, DAP-1 antibody, dap1a antibody, wu:fa16h08 antibody, wu:fc06d11 antibody, death associated protein antibody, death-associated protein antibody, death-associated protein S homeolog antibody, DAP antibody, Dap antibody, dap.S antibody, dap antibody

Background: DAP Antibody: The Death-associated protein (DAP) is a basic proline-rich 15  kDa protein that as a positive mediator of programmed cell death that is induced by interferon-gamma (1). DAP is also a direct substrate of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Under rich nutrient conditions, mTOR phosphorylates DAP at Ser3 and Ser51, under starvation conditions, these residues are dephosphorylated and DAP is converted into an active suppressor of autophagy (2).

Molecular Weight: Predicted: 11 kDa

Observed: 11 kDa

Gene ID: 1611

NCBI Accession: NP_004385

UniProt: P51397

Pathways: Positive Regulation of Endopeptidase Activity, Feeding Behaviour