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DIS3 antibody (AA 90-140)
DIS3
Reactivity: Human, Mouse, Rat
WB, ELISA, IF, IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-DIS3 Antibody
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Target
See all DIS3 Antibodies
DIS3
(Exosome Complex Exonuclease RRP44 (DIS3))
Binding Specificity
All epitopes for DIS3 antibodies
AA 90-140
Reactivity
All reactivities for DIS3 antibodies
Human, Mouse, Rat
Host
All hosts for DIS3 antibodies
Rabbit
Clonality
All clonalities for DIS3 antibodies
Polyclonal
Conjugate
All conjugates for DIS3 antibodies
This DIS3 antibody is un-conjugated
Application
All applications for DIS3 antibodies
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
Multiple isoforms of DIS3 are known to exist.
Purification
DIS3 Antibody is affinity chromatography purified via peptide column.
Immunogen
DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3. The immunogen is located within amino acids 90 - 140 of DIS3.
Isotype
IgG
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Discover our top product DIS3 Primary Antibody
Alternatives
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Application Details
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Application Notes
DIS3 antibody can be used for detection of DIS3 by Western blot at 1 - 2 μ,g/mL.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
DIS3 Antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
DIS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target Details for DIS3
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Target
DIS3
(Exosome Complex Exonuclease RRP44 (DIS3))
Alternative Name
DIS3 (DIS3 Products )
Synonyms
EXOSC11 antibody, KIAA1008 antibody, RP11-342J4.3 antibody, RRP44 antibody, bA555G22.1 antibody, dis3p antibody, DIS3 antibody, 2810028N01Rik antibody, RGD1304646 antibody, wu:fb08g12 antibody, dis3 antibody, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease antibody, DIS3 exosome endoribonuclease and 3'-5' exoribonuclease antibody, DIS3 antibody, Dis3 antibody, dis3 antibody, dis3.L antibody
Background
DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
Molecular Weight
Predicted: 105 kDa Observed: 103 kDa
Gene ID
22894
NCBI Accession
NP_055768
UniProt
Q9Y2L1
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