P2RX7 antibody (C-Term)

Catalog No. ABIN5690089

Product Details anti-P2RX7 Antibody

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P2RX7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.

Purification: P2RX7 antibody is affinity chromatography purified via peptide column.

Immunogen: P2RX7 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human P2RX7.

The immunogen is located within the last 50 amino acids of P2RX7.

Isotype: IgG

Application Details

Application Notes: P2RX7 antibody can be used for detection of P2RX7 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: P2RX7 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: P2RX7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for P2RX7

Target: P2RX7 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7))

Alternative Name: P2RX7 (P2RX7 Products)

Synonyms: p2xr7 antibody, P2RX7 antibody, P2X7 antibody, AI467586 antibody, P2X(7) antibody, P2X7R antibody, p2x7 antibody, purinergic receptor P2X 7 antibody, purinergic receptor P2X, ligand-gated ion channel, 7 antibody, P2X purinoceptor 7 antibody, P2RX7 antibody, p2rx7 antibody, LOC100458463 antibody, P2rx7 antibody

Background: The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1). This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2). Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2). Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4).

Molecular Weight: Predicted: 34, 47, 65 kDa

Observed: 54 kDa

Gene ID: 5027

NCBI Accession: NP_002553

UniProt: Q99572

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis