STAT2 antibody

Catalog No. ABIN5692942

The Rabbit Polyclonal anti-STAT2 antibody has been validated for WB, ICC, IF and FACS. It is suitable to detect STAT2 in samples from Human.

Quick Overview for STAT2 antibody (ABIN5692942)

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT2 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-STAT2 Antibody

Purpose: Anti-STAT2 Antibody Picoband®

Sequence: FQDQLHQLYS HSLLPVDIRQ YLAVWIEDQN WQEA

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-STAT2 Antibody Picoband® (ABIN5692942). Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human STAT2, which shares 73.5% and 76.5% amino acid (aa) sequence identity with mouse and rat STAT2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL
Immunocytochemistry/Immunofluorescence, 5 μg/mL
Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells1. Banninger, G., Reich, N. C. STAT2 nuclear trafficking. J. Biol. Chem. 279: 39199-39206, 2004. 2. Bluyssen, H. A. R., Levy, D. E. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by Stat1 and p48 for stable interaction with DNA. J. Biol. Chem. 272: 4600-4605, 1997. 3. Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE Jr (Apr 1995). "The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2". Nucleic Acids Res 23 (3): 459-63.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for STAT2

Target: STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))

Alternative Name: STAT2

Background:

Synonyms: Signal transducer and activator of transcription 2, p113, STAT2

Background: Signal transducer and activator of transcription 2 (STAT2) is a protein that in humans is encoded by the STAT2 gene. The protein encoded by this gene is a member of the STAT protein family. The International Radiation Hybrid Mapping Consortium mapped the STAT2 gene to chromosome 12. STAT2 is a transcription factor critical to the signal transduction pathway of type I interferons. ISGF3 (STAT2) assembly involves p48 functioning as an adaptor protein to recruit Stat1 and Stat2 to an IFN-alpha-stimulated response element, Stat2 contributes a potent transactivation domain but is unable to ly contact DNA, while Stat1 stabilizes the heteromeric complex by contacting DNA ly.

Molecular Weight: 113 kDa

Gene ID: 6773

UniProt: P52630

Pathways: JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events