EPOR antibody (AA 32-225)

Catalog No. ABIN5693050

The Rabbit Polyclonal anti-EPOR antibody is suitable to detect EPOR in samples from Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for EPOR antibody (AA 32-225) (ABIN5693050)

Target: EPOR (Erythropoietin Receptor (EPOR))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPOR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-EPOR Antibody

Binding Specificity: AA 32-225

Purpose: Anti-EPO Receptor/Epor Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-EPO Receptor/Epor Antibody (ABIN5693050). Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Immunogen: E. coli-derived mouse EPO Receptor recombinant protein (Position: D32-E225).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for EPOR

Target: EPOR (Erythropoietin Receptor (EPOR))

Alternative Name: Epor

Background:

Synonyms: Erythropoietin receptor, EPO-R, Epor

Tissue Specificity: Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells.

Background: The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

Molecular Weight: 55 kDa

Gene ID: 13857

UniProt: P14753

Pathways: JAK-STAT Signaling