INTS3 antibody

Catalog No. ABIN5697695

Product Details anti-INTS3 Antibody

Target: INTS3 (Integrator Complex Subunit 3 (INTS3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INTS3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Immunogen: integrator complex subunit 3

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for INTS3

Target: INTS3 (Integrator Complex Subunit 3 (INTS3))

Alternative Name: INTS3 (INTS3 Products)

Synonyms: INTS3 antibody, Ints3 antibody, NV18802 antibody, ACYPI009450 antibody, DL3335W antibody, FCAALL.260 antibody, embryo defective 2739 antibody, C1orf193 antibody, C1orf60 antibody, INT3 antibody, SOSS-A antibody, C77668 antibody, RGD1304593 antibody, si:dkey-27c15.2 antibody, integrator complex subunit 3 antibody, integrator complex subunit 3 L homeolog antibody, embryo defective 2739 antibody, INTS3 antibody, ints3.L antibody, CpipJ_CPIJ008133 antibody, ints3 antibody, Ints3 antibody, LOC100168776 antibody, emb2739 antibody

Background: Synonyms:C1orf193, C1orf60 Background:Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs(snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain(CTD) of RNA polymerase II largest subunit(POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks(DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.

Molecular Weight: 118 kDa

Gene ID: 65123

UniProt: Q68E01